In the Naruto manga, what is the last name of Tsunade?

The last name of Tsunade in the Naruto manga is Senju. Tsunade's full name is Tsunade Senju, and she belongs to the distinguished Senju clan. The Senju clan is renowned for its powerful and legendary ninja members, including Hashirama Senju, who was the co-founder of Konohagakure and the first Hokage. Tsunade, being a descendant of this prestigious clan, inherited their exceptional ninja skills and medical expertise.