Solid Snake is actually a clone from the DNA of Big Boss in the Metal Gear Solid series' history.

The statement is true. In the Metal Gear Solid series, Solid Snake is indeed a clone created from the DNA of Big Boss. This cloning process was carried out as part of the Les Enfants Terribles project, in which Big Boss' genetic material was used to create several clones, including Solid Snake and his twin brother Liquid Snake. This connection between Solid Snake and Big Boss plays a significant role in the narrative of the series, including their complex relationship and the themes of identity and destiny explored throughout the games.